NAD+ (nicotinamide adenine dinucleotide) has become the supplement that everyone in wellness circles is talking about — and the one that many clinicians are either extremely excited about or deeply skeptical of. As usual, the truth sits between the headlines.
What NAD+ Actually Does in the Body
NAD+ is a coenzyme present in every living cell. It's central to cellular energy metabolism — a key electron carrier in the mitochondrial electron transport chain, which is how your cells produce ATP. Beyond energy, NAD+ is a required cofactor for sirtuins (proteins involved in DNA repair, inflammation regulation, and aging) and for PARP enzymes (involved in DNA damage response).
Critically, NAD+ levels decline with age. By the time most people are in their 40s, their NAD+ levels may be 50% of what they were at 20. This decline is associated with reduced mitochondrial function, increased inflammation, and impaired cellular repair — processes central to how we experience aging.
What the Research Actually Shows
Animal studies on NAD+ precursors have shown remarkable results in extending healthspan and improving metabolic function. Human trials are earlier stage but encouraging, particularly in cognitive function and muscle physiology in older adults. The IV delivery method achieves substantially higher plasma levels than oral supplementation.
The honest caveat: much of the most compelling evidence comes from animal models. Anyone telling you IV NAD+ is a guaranteed anti-aging intervention is overstating the science. Anyone dismissing it entirely is ignoring a plausible mechanism with meaningful early evidence.
Who Is It Actually For?
At M Health, we recommend NAD+ infusions for patients experiencing cognitive fatigue, post-illness recovery (particularly post-viral syndromes), age-related energy decline, and high-performance athletes seeking enhanced recovery. If you're curious whether it makes sense for your situation, we recommend starting with a consultation.
